HMGCR and rheumatoid arthritis: Genetically proxied HMGCR inhibition equivalent to per standard deviation (SD) decrease in LDL-C was causally associated with a lower risk of RA in both discovery (OR = 0.45, 95%CI: 0.32, 0.63, P = 6.79 × 10− 06) and replicate datasets (OR = 0.37, 95%CI: 0.23, 0.61, P = 7.81 × 10− 05) after Bonferroni correction (Fig. 3 & Table S14-15 & Supplementary Fig. 3).