Hence, these factors were incorporated into subsequent MVMR analysis, and the findings indicated that HMGCR suppression was causally linked to a lower RA risk after controlling for the influence of SBP, BMI, and smoking (OR = 0.33, 95%CI = 0.40, 0.96, P = 0.042) (Table S28). This evidence concerns the gene HMGCR and rheumatoid arthritis.