Colocalization analyses were then performed to determine the likelihood whether genetic variants associated with HMGCR expression in relevant tissues shared causal loci with RA, and we found that for LDL and RA within the HMGCR gene, the respective probabilities of H4 were 22.22%; for Apo-B and RA within the HMGCR gene, the respective probabilities were 29.64% (Supplementary Fig. 4 & Table S26). Here, HMGCR is linked to rheumatoid arthritis.