AKT1 and hyperinsulinism: Insulin resistance is a pathological condition that results in hyperinsulinemia due to cells failing to respond to normal levels of insulin, which in turn activates downstream signaling pathways such as the phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) pathway, ultimately leading to abnormal proliferation and apoptosis of endometrial cells [11, 12].