NFE2L2 and rheumatoid arthritis: An important finding in the context of I/R injury is that miR-30a ameliorates oxidative stress via activation of nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) signaling pathway, however, this effect was studied in synovial fibroblasts of rheumatoid arthritis model and requires further investigation in hypoxia/reoxygenation cell culture models to investigate its therapeutic potential [57].