The TNF-α upregulates miR-17 and miR-31 in human umbilical vein endothelial cells (HUVECs) in which the miR-17 inhibits the ICAM-1 expression in a negative feedback loop while miR-31 downregulates eNOS pathway resulting in endothelial dysfunction [107, 108]. The gene discussed is TNF; the disease is endothelial dysfunction.