Study on obesity-associated inflammation have confirmed the role of miR-132 in the production of pro-inflammatory cytokines by direct targeting of SIRT1 and therefore inhibiting SIRT1-mediated downregulation of NF-κB pathway resulting in the increased production of MCP-1 and IL-8 in primary human pre-adipocytes and in vitro differentiated adipocytes [153, 154]. The gene discussed is SIRT1; the disease is Obesity.