SIRT1 and atherosclerosis: The miR-217 was found to be upregulated in old HUVECs, HAECs, and human coronary artery endothelial cells (HCAECs) and it was demonstrated that miR-217 modulates SIRT1/eNOS and SIRT1/FOXO1 axes to inhibit angiogenesis and promote atherosclerosis [153].