Components such as collagen, laminin, and fibronectin are integral to the TME structure, alongside extracellular matrix elements, cancer-associated fibroblasts (CAFs), and immunosuppressive cytokines like IL-10 and IL-17 (Buoncervello et al. 2019; Li et al. 2019; Rivas et al. 2021). The gene discussed is FN1; the disease is cancer.