For LC-NEC, TP53 mutated cases had lower RR (16 vs 43%, p = 0.033) whereas APC mutated cases had higher rate of immediate progression (77 vs 32%, p = 0.008) and shorter PFS (3.3 vs 1.8 m, p = 0.004). The gene discussed is TP53; the disease is laryngotracheoesophageal cleft.