ACTA1 and Bloom syndrome: BLM-induced mice exhibited extensive distortion, massive infiltration of inflammatory cells, and excessive collagen deposition, which were attenuated by DMM treatment (Fig. 7A,B). In addition, the Alveolitis scores (Fig. 7C) and Ashcroft scores (Fig. 7D) confirmed these findings. DMM also reduced BLM-induced protein elevations in BALFs (Fig. 7E). Western blot further verified that DMM treatment reduced α-SMA and FN expression in lung tissue of BLM induced mice (Fig. 7F–H).