RUNX2 and acute myeloid leukemia: To further validate apoptosis mediated by XBP1s expression observed in OCI-AML3 in a wider panel of AML cell lines, we established five additional tetracycline-inducible cell lines expressing the XBP1 spliced isoform: OCI-AML2, MOLM-14, MV4-11, THP1 and HL60 (Supplementary Fig. 3A).