Additionally, treatment with C-P4H inhibitor, Ethyl 3,4-dihydroxybenzoate (EDHB), phenocopied P4HA2 knockout effects, as shown in Supplementary Fig. 13A, B, indicating that EDHB targets P4HA2 in stromal fibroblast to delay B-cell lymphoma progression. Here, P4HA2 is linked to B-cell non-Hodgkin lymphoma.