This comprised complete male, but not female, infertility in Tent5c KO (Tent5c−/−), male infertility in Tent5d KO (Tent5d−/null), partial male infertility and complete infertility in Tent5a KO (Tent5a−/−) animals, and complete infertility in Tent5b/c double KO (dKO; Tent5b−/−Tent5c−/−) females (with one wild-type (WT) allele of either gene sufficient for normal fertility). The gene discussed is TENT5A; the disease is Infertility.