Interestingly, large deletions (>1.4 kb) with microhomologies at their break sites (which we assume to be primarily repaired by MMEJ) also showed a striking shift towards euchromatin in BRCA2-/- tumors compared to BRCA2+/+ HPVneg HNSCC (Supplementary Fig. 10F), consistent with N-synergy of BRCA2 with euchromatin. This evidence concerns the gene BRCA2 and head and neck squamous cell carcinoma.