Overexpression of C-type lectin receptor dendritic cell specific intercellular adhesion molecule-3-(ICAM-3) grabbing non integrin (DC-SIGN) or the liver/lymph node specific ICAM-3-grabbing non-integrin (L-SIGN) lead to an enhancement of NW Arenavirus infection, specifically for JUNV. Here, ICAM3 is linked to Arenaviridae infectious disease.