Livers of Plin5−/− mice displayed decreased lipid infiltration and inflammasome signalling molecules compared to wild-type when both groups were fed a HFD.83 Pan-activation of PPARs with the experimental drug IVA337 led to a decrease in Nlrp3, Casp1 and Nfkb expression, reducing liver inflammation, fibrosis and even promoting reversion of liver fibrosis in comparison to single PPAR agonists.84 This evidence concerns the gene CASP1 and Hepatic fibrosis.