Livers of Plin5−/− mice displayed decreased lipid infiltration and inflammasome signalling molecules compared to wild-type when both groups were fed a HFD.83 Pan-activation of PPARs with the experimental drug IVA337 led to a decrease in Nlrp3, Casp1 and Nfkb expression, reducing liver inflammation, fibrosis and even promoting reversion of liver fibrosis in comparison to single PPAR agonists.84 The gene discussed is NLRP3; the disease is Hepatic fibrosis.