IGHMBP2 and spinal muscular atrophy, type 1: In these analyses, IGHMBP2 and STRAP specifically co-immunoprecipitated with SNORD116. Mutations in IGHMBP2 are linked to spinal muscular atrophy, type 1 (SMARD1 [MIM: 604320]),112,113,114,115,116,117 which shows symptoms such as hypotonia, feeding problems, and poor suck.118