ACSL4 and Parkinson disease: Indeed, ACSL4 was elevated in the substantia nigra of PD and in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxication in mice, whereas reduction of ACSL4 protects against dopaminergic neuronal loss and motor deficits that are specifically linked with lipid peroxidation [540].