In the same way that ACSL4 and ACSL3 generally appear to have opposing roles in shaping the lipidome and ferroptotic sensitivity of cancer cells, LPCAT3 and the MBOAT1 and MBOAT2 enzymes may play opposing roles, with MBOAT1/2 being more specific for the insertion of MUFA-CoAs into membrane PLs, especially PEs [123]. This evidence concerns the gene ACSL4 and cancer.