The initial observation that 12/15-lipoxygenase may play a role in the cell death process downstream of GPX4 was, however, refuted by subsequent double knockout studies in mice showing that 12/15-lipoxygenase encoding Alox15 loss fails to rescue kidney failure [6], T cell development and homeostasis [86] and even embryogenesis [87]. The gene discussed is GPX4; the disease is kidney failure.