GPX4 and Crohn disease: A recent study reported that IECs in Crohn's disease indeed exhibit impaired GPX4 activity and an increase of 4-hydroxy-2-nonenal (4-HNE) immunoreactivity, indicating a vulnerability of IECs to ferroptosis in Crohn's disease [352], although the therapeutic potential of targeting ferroptosis for Crohn's disease remains elusive.