Nonetheless, cellular studies, where an important anti-ferroptotic function of mGPX4 was postulated in somatic cell including cancer cell lines, must be interpreted with care as overexpression of mGPX4 in somatic cells on a GPX4 knockout background may cause improper/insufficient mitochondrial matrix localization, thereby allowing survival of Gpx4-deleted cells. This evidence concerns the gene GPX4 and cancer.