The differences observed in LD parameters after GSK-3 inhibition could result from, at least in part, the tight regulation by the circadian clock as previously shown for the LD content (Monjes et al. 2022) and other metabolic parameters in different cancer cells (Wagner et al. 2018, 2019) (reviewed in (Guido et al. 2022)) as well as the differential response to pharmacological modulation of clock proteins. Here, CLOCK is linked to cancer.