Smoking-related lung cancer accounts for the majority of lung cancer diagnoses in the US and displays distinct epidemiological and genomic characteristics compared to non-smoking-related lung cancer.1,14 Studies show that the total number of single base substitutions (SBS) is approximately 5-fold higher in smoking-related vs non-smoking-related lung adenocarcinomas, with an average of 12.1 compared to 2.7 (P < .000001).22,23 Among smokers with lung adenocarcinoma, KRAS mutations are more prevalent, affecting 47% of tumors, with a dominance of G12C mutations. The gene discussed is KRAS; the disease is lung carcinoma.