NEFL and myeloid sarcoma: Estriol treatment in the MS model reduced hippocampal atrophy and cerebral cortex atrophy, while decreasing neuropathology therein.6,7 Studies of estriol treatment in MS women using an 8-mg dose to induce mid-pregnancy serum levels demonstrated improved cognitive processing speed, reduced cerebral cortex atrophy, and decreased serum neurofilament light chain levels, each as compared to placebo treatment and within 12 months.8, –10