More than half of the top 25 KEGG pathways enriched by the panel of genes corresponding to the filtered protein network overlapped on day 1 and 3, including several pro-inflammatory signaling pathways and OA-related pathways, such as “IL-17 signaling pathway,” “TNF signaling pathway,” and “rheumatoid arthritis” (Supplementary Table 4). The gene discussed is TNF; the disease is rheumatoid arthritis.