Subsequent proteomic analysis suggests that the ECM and intercellular communication play a robust role in development of neurofibromas and that MEK inhibition results in inhibition of the ECM profile and TGF-\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\upbeta$$\end{document}β signaling. The gene discussed is MAP2K7; the disease is neurofibroma.