While matching tumor sets may help control some variables such as background genomics and the same germline variant, matched tumor sets still have a different second hit or allelic inactivation (loss of heterozygosity) of NF1. We also did not define or control for either cNF tumor types or NF1 variant types (i.e. missense, nonsense, deletion, etc.)for either germline or somatic variants. This evidence concerns the gene NF1 and neoplasm.