After adjusting for age, sex, race, BMI, educational level, drinking status, smoking status, HDL-C, uric acid, eGFR, hypertension, and CKD, weighted multivariable regression analysis revealed that in the group without diabetes, the α-Klotho level decreased by 32.35 pg/ml (95% CI: -50.07, -14.64) for every one unit increase in TyG (p < 0.001). Here, KL is linked to Hypertension.