According to a recent study, HSP47 negatively correlates with E-cadherin (an epithelial marker) and positively with N-cadherin, MMP2, and MMP9 (markers associated with mesenchymal phenotype and invasion) and plays a critical role in GC progression through its regulation of epithelial-mesenchymal transition (EMT) and the Wnt/β-catenin signaling pathway [12]. The gene discussed is SERPINH1; the disease is gastric cancer.