However, DNA NGS from liver metastatic biopsies revealed, along with the clonal CTNNB1 gain-of-function mutation (D32N), molecular findings characteristic for PCa, such as the presence of a TMPRSS2 rearrangement, a loss-of-function mutation in TP53 (R282W), and PTEN loss. Here, CTNNB1 is linked to posterior cortical atrophy.