Due to the implications of SWI/SNF complex-targeting agents in AR-driven PCa [26] and Wnt-driven PCa [16] fxc, we included the BRD9 and BRD7 proteolysis-targeting chimera (PROTAC) degrader VZ185 [27, 28], the PROTAC degraders of SMARCA2 and SMARCA4 (subunits of the SWI/SNF complex) AU15330, A947, ACBI1, and the dual SMARCA4/SMARCA2 inhibitor FH286. The gene discussed is SMARCA1; the disease is posterior cortical atrophy.