GPT and neutropenia: Grade 3 toxicities in all patients were leukopenia (5.08%), neutropenia (4.24%), lymphopenia (2.12%), thrombocytopenia (1.69%), anemia (1.27%), ALT increased (0.42%), AST increased (0.42%), proteinuria (1.69%), decreased appetite (0.42%), vomiting (0.85%), diarrhea (0.42%), hypertension (1.27%), palmar-plantar erythrodysesthesia symptoms (2.12%), leukoencephalopathy (0.42%), memory impairment (0.85%), and depression (0.42%); Grade 4 adverse events included neutropenia (2.12%), thrombocytopenia (2.12%) and proteinuria (1.69%).