Coupled with the upregulation of ALS–FTD-associated genes SQSTM1/p62, OPTN, TREM2 and GRN, this suggests a mechanistic convergence on vesicle trafficking and inflammatory pathways that may initiate/exacerbate the homeostatic-to-DAM transition in ALS7. The gene discussed is OPTN; the disease is amyotrophic lateral sclerosis.