In agreement with this finding, in LA-treated PCa cells we observed the upregulate of Col1a1 chain only (Fig. EV5B), while human CAFs actively express both a1 and a2 chains (Col1a2), suggesting that differential collagen oligomerization in stromal and cancer cells may be critical for DDR1 activation. The gene discussed is COL1A2; the disease is posterior cortical atrophy.