Altogether, we found that the NF-κB signaling pathway regulates the expression of multiple molecules commonly associated with the neurotoxic pro-inflammatory phenotype of astrocytes (i.e., high GFAP, IL6, and KC) and with the neuroprotective phenotype of these cells (i.e., AQP4) in a mouse model of AD. This evidence concerns the gene CALCA and Alzheimer disease.