We further analyzed the expression of MT1G in renal clear cell carcinoma tubular epithelial cellswith different malignant progression stages in GSE224630 single cell data, and found that the expression of MT1G in tubular epithelial cells increased with increasing malignant stage (Fig. 1k).These findings suggest that MT1G may play a tumor-promoting role during ccRCC progression. This evidence concerns the gene MT1G and nonpapillary renal cell carcinoma.