Equal weight of subcutaneous tumor from MT1G-overexpressing cells and control cells carrying a luciferase/GFP reporter gene were injected into right kidney of NVSG mice, and the effect of MT1G expression on the growth of renal orthotopic tumor was analyzed by live imaging, and these results showed that MT1G overexpression promoted the renal clear cell carcinoma growth in situ (Fig. 2d). Here, MT1G is linked to neoplasm.