While the CJ:KREC ratio was strikingly similar between the CVID subgroups (mean of 12.62 ± 10.5 vs. 13.61 ± 10.2, Fig. 1C), the BAFF level was substantially higher in the CVID with lymphoproliferation cohort (mean of 372.4 ± 361 pg/mLvs 60.15 ± 20.9 pg/mL, Fig. 1D), and when compared across all groups this achieved statistical significance (p = 0.031),. This evidence concerns the gene TNFSF13B and common variable immunodeficiency.