In brain cancer (OS MGH-glioma (136 sample)27, HR = 0.45, P = 0.001434), blood cancer (OS GSE = 12,417-GPL570(163 sample)29,30, HR = 1.19, P = 0.013093), and ovarian cancer (OS GSE = 9891(285 sample)31, HR = 0.26, P = 0.016982), high expression of NOTCH3 was likewise linked to a poor prognosis. The gene discussed is NOTCH3; the disease is hematopoietic and lymphoid system neoplasm.