We further found NOTCH3 levels in gastrointestinal tumor to correlate with markers of Dendritic cell(HLA-DPB1, HLA-DRA, HLA-DPA1, BDCA-4), Tfh(T-bet, STAT4, STAT1, TNF-α), Treg cells (FOXP3, CCR8, STAT5B, TGFβ) and T cell exhaustion (PD-1, CTLA4, LAG3, TIM-3) (Table 2). Here, NRP1 is linked to digestive system neoplasm.