While no significant correlation was found between prognosis and immune cell infiltration or NOTCH3 expression (P > 0.05) in LIHC and PAAD (Fig. 4F,G), we did find that NOTCH3 expression (P = 0.032) significantly correlated with COAD prognosis and macrophage infiltration (P = 0.004) with STAD prognosis (Fig. 4E,H). Here, NOTCH3 is linked to colon adenocarcinoma.