In the remaining three patients for the same family, we discovered an 8.771 kb homozygous deletion within SPG11. There are a total of 24 large genomic deletion variants in SPG11 associated with autosomal recessive spastic paraplegia (http://www.hgmd.cf.ac.uk/ac/gene.php, accessed February 2024). The gene discussed is SPG11; the disease is hereditary spastic paraplegia 5A.