TGFB1 and Alzheimer disease: While there is some discrepancy in whether human Tgfb1 gene expression also enriches in microglia in the human CNS (with several published datasets supporting enriched Tgfb1 expression in microglia, one study showing differences in control vs AD subjects in microglial-Tgfb1 expression pattern22–25), our mouse MG-Tgfb1 adult iKO transcriptomic analysis show many overlapping upregulated or downregulated DEGs (differentially expressed genes) with a human cultured microglial-like cell transcriptomic dataset after TGF-β withdrawal, supporting the potential relevance of our study in human cells.