Interestingly, expression of RHNO1 (which encodes RHINO) and HUS1 were negatively correlated with survival in TP53-mutant GBM but not TP53-WT (Fig. 8G), suggesting that checkpoint defects in TP53-mutant GBMs render them reliant on mitotic MMEJ to survive treatment. The gene discussed is TP53; the disease is glioblastoma.