However, no differential expression was detected for BTK, BCL2, CD38, MCL1, NOTCH1, SF3B1 and TP53. Additionally, they identified 13 distinct subnetworks (modules) of dysregulated protein-coding genes, 8 of which were correlated with CLL relapse – 5 with positive correlation, 3 with negative correlation. Here, NOTCH1 is linked to B-cell chronic lymphocytic leukemia.