Other RT clusters were characterized by the differential expression of CCND2, MIR155HG and TP53INPI. It is suggested that RT is transcriptionally and epigenetically reminiscent of the de novo DLBCL CLL subtype, which is characterized insensitivity to BCR inhibition and high oxidative phosphorylation (OXPHOS), which could explain rapid expansion of RT subclones under therapy of BCR inhibitors [156]. Here, BCR is linked to B-cell chronic lymphocytic leukemia.