RGS16 and cancer: Through the utilization of a tissue microarray encompassing 37 normal colorectal tissues, 38 colorectal para-cancer tissues, 899 CRC tissues, and 16 metastatic CRC samples, along with an IHC analysis to discern the expression of RGS16 protein, we conducted a screening of positive signals and computed the IHC score to quantify the degree of RGS16 expression in each tissue sample.