The Ki67 labeling of tumor tissue depicted a positive correlation between RGS16 and tumor cell proliferation activity, whereas the Tunel assay and immunohistochemistry staining of cleaved caspase 3 exhibited negative association between RGS16 and apoptosis levels in tumor cells (Fig. 5D–F and Supplementary Fig. S4D–F). This evidence concerns the gene CASP3 and neoplasm.