RPLP1 and HIV-1 infection: Similarly, stable over-expression of RPLP1 in MT-4 cells showed lower susceptibility to HIV-1 infection and lower mRNA levels of viral rev, vpu, vif, and gag genes, while knock-down of RPLP1 expression by ~50% significantly enhanced susceptibility to HIV-1 infection and higher mRNA levels (Supplementary Fig. 1a, b).