We further investigated the release of DAMPs in NPC cells treated with docetaxel and found that knockdown of PJA1 increased both the release of HMGB1 from the nucleus into the cytoplasm (Fig. 6f, g and Supplementary Fig. 6a) and the cell surface expression of calreticulin (Fig. 6h and Supplementary Fig. 6b). This evidence concerns the gene PJA1 and nasopharyngeal carcinoma.