GSDME and neoplasm: Since it has been reported that chemotherapy drugs, such as cisplatin, doxorubicin and etoposide, can induce pyroptosis through caspase-3-mediated GSDME cleavage in tumour cells with high expression of GSDME10,25, we hypothesised that PJA1 may suppress docetaxel-induced pyroptosis to facilitate docetaxel resistance.