On the contrary, TMEM255A mRNA was not induced by mutant p53s expressed in cancer cells, such as MIA-PaCa-2 cells (expressing p53 R248W) and Panc-1 cells (expressing p53 R273H) (Figs 6D and S3F), in which the perinuclear accumulation of H3K27me3 was observed (Fig S3F and G). This evidence concerns the gene TMEM255A and cancer.