C9orf72 and amyotrophic lateral sclerosis: By comparison, we analysed treatment with edaravone (EDV), a known ROS scavenger and an FDA-approved ALS drug, as a positive control, and observed that 24-h treatment with 30 and 100 μM EDV reduced ROS levels in C9orf72 iNeurons to a similar extent as DMF (Fig S3E–G).