TNF and rheumatoid arthritis: Research has found that Tofacitinib is able to keep the expression of inflammatory factors to a certain extent, thus reducing the damage of inflammation to articular chondrocytes.[32] Clenoliximab is a chimeric monoclonal antibody against CD4 from rhesus monkeys, which has immunomodulatory effects.[33] Baricitinib is a Janus kinase (JAK) inhibitor used for the treatment of moderate to severe rheumatoid arthritis that does not respond well to at least one TNF antagonist.