THL may act on ALB, EGFR, HSP90AA1, ESR1, and other biological targets through quercetin, salidroside, oleanolic acid and other active components, participate in many signal pathways such as Pathways in cancer, Lipid and atherosclerosis, IL-17 signaling pathway to intervene with PN, and play anti-tumor, anti-cancer cell proliferation, anti-inflammation, anti-oxidation, etc. This study is based on scientific theories to speculate on the mechanism of THL intervention in PN, providing a theoretical basis for its secondary development. This evidence concerns the gene ESR1 and cancer.