SERPINE1 and melanoma: Furthermore, the ARCAP protein was identified as a co-regulator capable of interacting with AR in the liver, with high expression observed in both liver cancer cell lines and adjacent tumors.[30] Samarkina A investigation revealed a notable elevation in AR expression within BRAFi resistant melanoma cells, as well as in sensitive cells following brief exposure to BRAFi.[31] Feng L found that SERPINE1 exhibits high expression in gastric cancer, which is linked to an unfavorable prognosis.