This is achieved by suppressing the interleukin-17 and boosting the secretion of IL-10.[55] Furthermore, exposure to commensal luminal bacteria has been found to stimulate the production of IL-12,[56] which is considered to be involved in autoimmune diseases induced by bacterial products.[57] These findings emphasize the central role of inflammatory proteins in regulating the balance between gut microbiota and host health, providing us with new perspectives on studying the pathogenesis of CD and UC. The gene discussed is IL17A; the disease is autoimmune disease.