AGT and Hypertension: To address this, we expanded our MI map to include available CF scRNA-seq data from three additional disease models comprising single late-disease time points for ischemia-reperfusion injury (IRI) (day 5) (62), as well as angiotensin II (AngII)–induced and trans-aortic constriction (TAC)–induced hypertension associated with cardiac hypertrophic cardiomyopathy (days 14 and 62, respectively) (51, 63)—in humans, chronic disease states reflecting heart failure with reduced ejection fraction (HFrEF) (Fig. 4A).