Injury-induced populations were highest for TFs related to cell proliferation, self-renewal, and cancer involving both intrinsic (E2F family, MYC, and ZFX) and extrinsic (HIF1a, EPAS1/HIF2a, NFYB, LEF1, GLI2, VDR, and SMAD1/3/5) pathways. This evidence concerns the gene LEF1 and cancer.