To address this, we expanded our MI map to include available CF scRNA-seq data from three additional disease models comprising single late-disease time points for ischemia-reperfusion injury (IRI) (day 5) (62), as well as angiotensin II (AngII)–induced and trans-aortic constriction (TAC)–induced hypertension associated with cardiac hypertrophic cardiomyopathy (days 14 and 62, respectively) (51, 63)—in humans, chronic disease states reflecting heart failure with reduced ejection fraction (HFrEF) (Fig. 4A). This evidence concerns the gene AGT and heart failure.