Unexpectedly, KCNK1 binds to and activates LDHA, facilitates the process of glycolysis, catalyzes a new epigenetic modification–histone lysine lactylation, and stimulates the expression of a series of downstream genes related to cell proliferation, invasion, and metastasis, resulting in change of biophysical properties of breast cancer cells. This evidence concerns the gene KCNK1 and breast cancer.