The results revealed that overexpression of KCNK1 augmented pan histone and H3K18 lactylation in breast cancer cells, whereas pan histone and H3K18 lactylation were significantly inhibited after KCNK1 knockdown (S9A Fig), suggesting that KCNK1 was indeed involved in regulating histone lactylation in breast cancer cells. The gene discussed is KCNK1; the disease is breast cancer.