IFNAR1 and infection: However, unexpectedly, PoRVA infection promoted PEDV replication in IFNAR1-deficient (IFNAR1-/-) IPEC-J2 cells, and the RVA-HNNY strain promoted PEDV replication more strongly than the RVA-SXXA strain in both IFNAR1-/- cells and wild-type (WT) cells (Fig 3A and 3B).