Our previous studies have shown that JMJD2D can promote colorectal cancer progression by enhancing Wnt/β-catenin, Hedgehog, and HIF1 signaling pathways [16–18], and protect intestine from DSS-induced colitis by activating Hedgehog signaling [17], however, its role in C. rodentium-induced colitis remains unclear. Here, KDM4D is linked to colitis.