MYC and neuroblastoma: Nonetheless, increasing cellular growth through the overexpression of a constitutive active form of the PI3K catalytic subunit Dp110 (Dp110CAAX; Leevers et al., 1996), or the activation of the cellular growth regulator Myc (Rust et al., 2018) in clones did not prolong NB persistence in the OLs at 24 hr APF (Figure 1—figure supplement 1A, B, E, F).