Elevated glucose levels and AGEs stimulate the expression of sclerostin, a negative regulator of bone formation [64], and consequently, osteoprotegerin, a known inhibitor of bone resorption which has been observed to be positively associated with insulin resistance in postmenopausal women [65], with higher levels reported among T2DM as compared to non-T2DM individuals [66]. The gene discussed is SOST; the disease is type 2 diabetes mellitus.