FOLH1 and neoplasm: [18F]1 showed a lower uptake in the tumour expressed as SUV max after 60 and 120 min (1.11 ± 0.24 and 0.94 ± 0.12) compared to [18F]F-PSMA-1007 (1.48 ± 0.29 and 1.60 ± 0.44) (Fig. 4A and Additional file 1: S69B) but uptake expressed as ratio between tumour and muscle (30.29 ± 10.46 at 60’ and 83.53 ± 48.71 at 120’ for [18F]F-PSMA-617-NODA; 7.46 ± 1.55 at 60’ and 11.99 ± 6.16 at 120’ for [18F]F-PSMA-1007) (Fig. 4B and Additional file 1: S69C) was significantly higher for [18F]1, as also visible in the PET images (Fig. 4C).