However, in contrast to our methylomes showing overall hypomethylation of these ZFP genes in the SETDB1-KO cells, the methylomes from oropharyngeal squamous cell carcinoma [47] and the peripheral mononuclear cells (PBMCs) collected from the aging population [48] showed enrichment of hypermethylation across the ZFP gene clusters. The gene discussed is SETDB1; the disease is oropharynx squamous cell carcinoma.