SETDB1 and hereditary disease: Guided by these transcription factors, SETDB1 silences a range of genes, depending on the cellular context, that are involved in nervous system development, cell division, proliferation, immune cell regulation, etc. Dysregulation in SETDB1 expression is associated with tumorigenesis, neuropsychiatric and genetic disorders, as well as cardiovascular and gastrointestinal ailments [16].